The Best Comedy-Drama TV Shows Ever

About the TV show: When Buy More computer geek Chuck Bartowski unwittingly downloads a database of government information and deadly fighting skills into his head, he becomes the CIA's most vital secret. This sets Chuck on a path to become a full-fledged spy.

About the TV show: Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

About the TV show: Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.

About the TV show: In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.

About the TV show: Thanks to his police officer father's efforts, Shawn Spencer spent his childhood developing a keen eye for detail (and a lasting dislike of his dad). Years later, Shawn's frequent tips to the police lead to him being falsely accused of a crime he solved. Now, Shawn has no choice but to use his abilities to perpetuate his cover story: psychic crime-solving powers, all the while dragging his best friend, his dad, and the police along for the ride.

About the TV show: After a serial killer imitates the plots of his novels, successful mystery novelist Richard "Rick" Castle receives permission from the Mayor of New York City to tag along with an NYPD homicide investigation team for research purposes.

About the TV show: Neal Caffrey, a con man, forger and thief, is captured after a three-year game of cat and mouse with the FBI. With only months left serving a four-year sentence, he escapes to look for Kate, his girlfriend. Peter Burke, the FBI agent who initially captured Caffrey, finds and returns him to prison. This time, Caffrey proposes a deal with the FBI, as part of a work-release program. After some hesitation, Burke agrees, and thus begins this unconventional arrangement where Caffrey helps Burke apprehend white collar criminals.

About the TV show: The 4077th Mobile Army Surgical Hospital is stuck in the middle of the Korean war. With little help from the circumstances they find themselves in, they are forced to make their own fun. Fond of practical jokes and revenge, the doctors, nurses, administrators, and soldiers often find ways of making wartime life bearable.

About the TV show: Chicagoan Frank Gallagher is the proud single dad of six smart, industrious, independent kids, who without him would be... perhaps better off. When Frank's not at the bar spending what little money they have, he's passed out on the floor. But the kids have found ways to grow up in spite of him. They may not be like any family you know, but they make no apologies for being exactly who they are.

About the TV show: Set in the charming town of Stars Hollow, Connecticut, the series follows the captivating lives of Lorelai and Rory Gilmore, a mother/daughter pair who have a relationship most people only dream of.

About the TV show: In the year 2517, after the arrival of humans in a new star system, follow the adventures of the renegade crew of Serenity, a "Firefly-class" spaceship. The ensemble cast portrays the nine characters who live on Serenity.

About the TV show: Into every generation a slayer is born: one girl in all the world, a chosen one. She alone will wield the strength and skill to fight the vampires, demons, and the forces of darkness; to stop the spread of their evil and the swell of their number. She is the Slayer.

About the TV show: Looking down on her friends and family isn't a way of life for Mary Alice Young... it's a way of death. One day, in her perfect house, in the loveliest of suburbs, Mary Alice ended it all. Now she's taking us into the lives of her family, friends and neighbors, commenting from her elevated P.O.V.

About the TV show: A crime she committed in her youthful past sends Piper Chapman to a women's prison, where she trades her comfortable New York life for one of unexpected camaraderie and conflict in an eccentric group of fellow inmates.

About the TV show: A medical student who becomes a zombie joins a Coroner's Office in order to gain access to the brains she must reluctantly eat so that she can maintain her humanity. But every brain she eats, she also inherits their memories and must now solve their deaths with help from the Medical examiner and a police detective.